Prostaglandin E1 Inhibited Diabetes-Induced Phenotypic Switching of Vascular Smooth Muscle Cells Through Activating Autophagy

Prostaglandin E1 Inhibited Diabetes-Induced Phenotypic Switching of Vascular Smooth Muscle Cells Through Activating Autophagy

Background/Aims: The phenotype switching of vascular smooth muscle cells (VSMCs) was associated with the onset or progression of the atherogenic process in type 2 diabetes mellitus (T2DM). Alprostadil (Prostaglandin E1, PGE1) as a bioactive drug had a protective effect on vascular function. However,...

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Bibliographic Details
Main Authors: Xing-Rong An, Xin Li, Wei Wei, Xiao-Xue Li, Ming Xu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-10-01
Series:Cellular Physiology and Biochemistry
Subjects:
Diabetes
Phenotype switching
Autophagy
AKT
MTOR
PGE1
Online Access:https://www.karger.com/Article/FullText/494240

Internet

https://www.karger.com/Article/FullText/494240

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