Synergy of Venetoclax and 8-Chloro-Adenosine in AML: The Interplay of rRNA Inhibition and Fatty Acid Metabolism

Synergy of Venetoclax and 8-Chloro-Adenosine in AML: The Interplay of rRNA Inhibition and Fatty Acid Metabolism

It is known that 8-chloro-adenosine (8-Cl-Ado) is a novel RNA-directed nucleoside analog that targets leukemic stem cells (LSCs). In a phase I clinical trial with 8-Cl-Ado in patients with refractory or relapsed (R/R) AML, we observed encouraging but short-lived clinical responses, likely due to int...

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Bibliographic Details
Main Authors: Dinh Hoa Hoang, Corey Morales, Ivan Rodriguez Rodriguez, Melissa Valerio, Jiamin Guo, Min-Hsuan Chen, Xiwei Wu, David Horne, Varsha Gandhi, Lisa S. Chen, Bin Zhang, Vinod Pullarkat, Steven T. Rosen, Guido Marcucci, Ralf Buettner, Le Xuan Truong Nguyen
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cancers
Subjects:
acute myeloid leukemia
venetoclax
8-chloro-adenosine
rRNA synthesis
metabolism
Online Access:https://www.mdpi.com/2072-6694/14/6/1446

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https://www.mdpi.com/2072-6694/14/6/1446

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