A Signaling Factor Linked to Toxoplasma gondii Guanylate Cyclase Complex Controls Invasion and Egress during Acute and Chronic Infection

A Signaling Factor Linked to Toxoplasma gondii Guanylate Cyclase Complex Controls Invasion and Egress during Acute and Chronic Infection

ABSTRACT Toxoplasma gondii is an intracellular apicomplexan parasite that relies on cyclic GMP (cGMP)-dependent signaling to trigger timely egress from host cells in response to extrinsic and intrinsic signals. A guanylate cyclase (GC) complex, conserved across the Apicomplexa, plays a pivotal role...

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Bibliographic Details
Main Authors: Shu Ye, Matteo Lunghi, Dominique Soldati-Favre
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:mBio
Subjects:
Toxoplasma gondii
signaling
guanylate cyclase
invasion
egress
bradyzoite
Online Access:https://journals.asm.org/doi/10.1128/mbio.01965-22

Internet

https://journals.asm.org/doi/10.1128/mbio.01965-22

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