The RhoJ-BAD signaling network: An Achilles' heel for BRAF mutant melanomas.

The RhoJ-BAD signaling network: An Achilles' heel for BRAF mutant melanomas.

Genes and pathways that allow cells to cope with oncogene-induced stress represent selective cancer therapeutic targets that remain largely undiscovered. In this study, we identify a RhoJ signaling pathway that is a selective therapeutic target for BRAF mutant cells. RhoJ deletion in BRAF mutant mel...

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Bibliographic Details
Main Authors: Rolando Ruiz, Sohail Jahid, Melissa Harris, Diego M Marzese, Francisco Espitia, Priya Vasudeva, Chi-Fen Chen, Sebastien de Feraudy, Jie Wu, Daniel L Gillen, Tatiana B Krasieva, Bruce J Tromberg, William J Pavan, Dave S Hoon, Anand K Ganesan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-07-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5549996?pdf=render

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http://europepmc.org/articles/PMC5549996?pdf=render

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