Angelica Polysaccharide Antagonizes 5-FU-Induced Oxidative Stress Injury to Reduce Apoptosis in the Liver Through Nrf2 Pathway

Angelica Polysaccharide Antagonizes 5-FU-Induced Oxidative Stress Injury to Reduce Apoptosis in the Liver Through Nrf2 Pathway

Oxidative stress induced by chemotherapeutic agents causes hepatotoxicity. 5-Fluorouracil (5-FU) has been found to have a variety of side effects, but its toxic effect on the liver and the mechanism are still unclear. Angelica polysaccharide (ASP), the main active ingredient of Dang Gui, has antioxi...

Full description

Bibliographic Details
Main Authors: Di Zeng, Yaping Wang, Yi Chen, Danyang Li, Guoli Li, Hanxianzhi Xiao, Jiyin Hou, Ziling Wang, Ling Hu, Lu Wang, Jing Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Oncology
Subjects:
5-fluorouracil
ASP
oxidative stress
Nrf2
hepatotoxicity
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.720620/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.720620/full

Similar Items