Discovery of decreased ferroptosis in male colorectal cancer patients with KRAS mutations

Discovery of decreased ferroptosis in male colorectal cancer patients with KRAS mutations

Aberrant tumor metabolism is a hallmark of cancer in which metabolic rewiring can support tumor growth under nutrient deficient conditions. KRAS mutations occur in 35–45% of all colorectal cancer (CRC) cases and are difficult to treat. The relationship between mutant KRAS and aberrant metabolism in...

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Bibliographic Details
Main Authors: Hong Yan, Ronan Talty, Abhishek Jain, Yuping Cai, Jie Zheng, Xinyi Shen, Engjel Muca, Philip B. Paty, Marcus W. Bosenberg, Sajid A. Khan, Caroline H. Johnson
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Redox Biology
Subjects:
KRAS
Colorectal cancer
Ferroptosis
Sex differences
Metabolomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723001003

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http://www.sciencedirect.com/science/article/pii/S2213231723001003

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