Heparanase-Dependent Remodeling of Initial Lymphatic Glycocalyx Regulates Tissue-Fluid Drainage During Acute Inflammation in vivo

Heparanase-Dependent Remodeling of Initial Lymphatic Glycocalyx Regulates Tissue-Fluid Drainage During Acute Inflammation in vivo

The glycocalyx is a dense layer of carbohydrate chains involved in numerous and fundamental biological processes, such as cellular and tissue homeostasis, inflammation and disease development. Composed of membrane-bound glycoproteins, sulfated proteoglycans and glycosaminoglycan side-chains, this st...

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Bibliographic Details
Main Authors: Samantha Arokiasamy, Ross King, Hidayah Boulaghrasse, Robin N. Poston, Sussan Nourshargh, Wen Wang, Mathieu-Benoit Voisin
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
glycocalyx
lymphatic vessels
neutrophil trafficking
inflammation
lectins
heparan sulfate
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02316/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02316/full

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