Combined Live Oral Priming and Intramuscular Boosting Regimen with Rotarix<sup>®</sup> and a Nanoparticle-Based Trivalent Rotavirus Vaccine Evaluated in Gnotobiotic Pig Models of G4P[6] and G1P[8] Human Rotavirus Infection

Combined Live Oral Priming and Intramuscular Boosting Regimen with Rotarix<sup>®</sup> and a Nanoparticle-Based Trivalent Rotavirus Vaccine Evaluated in Gnotobiotic Pig Models of G4P[6] and G1P[8] Human Rotavirus Infection

Human rotavirus (HRV) is the causative agent of severe dehydrating diarrhea in children under the age of five, resulting in up to 215,000 deaths each year. These deaths almost exclusively occur in low- and middle-income countries where vaccine efficacy is the lowest due to chronic malnutrition, gut...

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Bibliographic Details
Main Authors: Casey Hensley, Charlotte Nyblade, Peng Zhou, Viviana Parreño, Ashwin Ramesh, Annie Frazier, Maggie Frazier, Sarah Garrison, Ariana Fantasia-Davis, Ruiqing Cai, Peng-Wei Huang, Ming Xia, Ming Tan, Lijuan Yuan
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Vaccines
Subjects:
rotavirus nanoparticle
gnotobiotic pig
priming immunization
Online Access:https://www.mdpi.com/2076-393X/11/5/927

Internet

https://www.mdpi.com/2076-393X/11/5/927

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