Polydatin Glycosides Improve Monocrotaline-Induced Pulmonary Hypertension Injury by Inhibiting Endothelial-To-Mesenchymal Transition

Polydatin Glycosides Improve Monocrotaline-Induced Pulmonary Hypertension Injury by Inhibiting Endothelial-To-Mesenchymal Transition

Objective: To study the effect of polydatin on the injury of pulmonary arterial hypertension (PAH) induced by monocrotaline (MCT).Methods: SD rats were induced to develop PAH injury by a single subcutaneous injection of MCT (60 mg/kg). From the second day, rats in the administration group were orall...

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Bibliographic Details
Main Authors: Xing Chen, Yao He, Zhijie Yu, Jianli Zuo, Yan Huang, Yi Ruan, Xiaoyuan Zheng, Yu Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
polydatin
pulmonary arterial hypertension
EndMT
HIF-2α
Arg1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.862017/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.862017/full

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