High Heme and Low Heme Oxygenase-1 Are Associated with Mast Cell Activation/Degranulation in HIV-Induced Chronic Widespread Pain

High Heme and Low Heme Oxygenase-1 Are Associated with Mast Cell Activation/Degranulation in HIV-Induced Chronic Widespread Pain

An overwhelming number of people with HIV (PWH) experience chronic widespread pain (CWP) throughout their lifetimes. Previously, we demonstrated that PWH with CWP have increased hemolysis and attenuated heme oxygenase 1 (HO-1) levels. HO-1 degrades reactive, cell-free heme into antioxidants like bil...

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Bibliographic Details
Main Authors: Tanima Chatterjee, Itika Arora, Lilly Underwood, Anastasiia Gryshyna, Terry L. Lewis, Juan Xavier Masjoan Juncos, Burel R. Goodin, Sonya Heath, Saurabh Aggarwal
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Antioxidants
Subjects:
HIV
cell-free heme
heme oxygenase
mast cells
chronic widespread pain
Online Access:https://www.mdpi.com/2076-3921/12/6/1213

Internet

https://www.mdpi.com/2076-3921/12/6/1213

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