Three Birds, One Stone: An Osteo‐Microenvironment Stage‐Regulative Scaffold for Bone Defect Repair through Modulating Early Osteo‐Immunomodulation, Middle Neovascularization, and Later Osteogenesis

Three Birds, One Stone: An Osteo‐Microenvironment Stage‐Regulative Scaffold for Bone Defect Repair through Modulating Early Osteo‐Immunomodulation, Middle Neovascularization, and Later Osteogenesis

Abstract In order to repair critical‐sized bone defects, various polylactic acid‐glycolic acid (PLGA)‐based hybrid scaffolds are successfully developed as bone substitutes. However, the byproducts of these PLGA‐based scaffolds are known to acidify the implanted site, inducing tiresome acidic inflamm...

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Bibliographic Details
Main Authors: Yuhao Yuan, Yan Xu, Yiyang Mao, Hongbin Liu, Minning Ou, Zhangyuan Lin, Ruibo Zhao, Haitao Long, Liang Cheng, Buhua Sun, Shushan Zhao, Ming Zeng, Bangbao Lu, Hongbin Lu, Yong Zhu, Can Chen
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:Advanced Science
Subjects:
3D‐printed scaffold
bone regeneration
decellularized bone matrix
magnesium hydroxide
osteo‐microenvironment
Online Access:https://doi.org/10.1002/advs.202306428

Internet

https://doi.org/10.1002/advs.202306428

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