Lessons from two prevalent amyloidoses - what amylin and Aβ have in common

The amyloidogenic peptide Aβ plays a key role in Alzheimer's disease (AD) forming insoluble aggregates in the brain. The peptide shares its amyloidogenic properties with amylin that forms aggregates in the pancreas of patients with Type 2 Diabetes mellitus (T2DM). While epidemiological studi...

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Bibliographic Details
Main Authors: Jurgen eGotz, Yun-An eLim, Anne eEckert
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00038/full