Building-block architecture of botulinum toxin complex: Conformational changes provide insights into the hemagglutination ability of the complex

Building-block architecture of botulinum toxin complex: Conformational changes provide insights into the hemagglutination ability of the complex

Clostridium botulinum produces the botulinum neurotoxin (BoNT). Previously, we provided evidence for the “building-block” model of botulinum toxin complex (TC). In this model, a single BoNT is associated with a single nontoxic nonhemagglutinin (NTNHA), yielding M-TC; three HA-70 molecules are attach...

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Bibliographic Details
Main Authors: Tomonori Suzuki, Yoshimasa Sagane, Takashi Matsumoto, Kimiko Hasegawa, Akihito Yamano, Koichi Niwa, Toshihiro Watanabe
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Biochemistry and Biophysics Reports
Subjects:
Hemagglutination
Botulinum neurotoxin
Small-angle X-ray scattering
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580816302965

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http://www.sciencedirect.com/science/article/pii/S2405580816302965

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