An extracellular humanized IFNAR immunocompetent mouse model for analyses of human interferon alpha and subtypes

An extracellular humanized IFNAR immunocompetent mouse model for analyses of human interferon alpha and subtypes

ABSTRACTType I interferons (IFN-Is) have key roles in immune defense and treatments for various diseases, including chronic hepatitis B virus (HBV) infection. All IFN-Is signal through a shared IFN-I heterodimeric receptor complex comprising IFN-α receptor 1 (IFNAR1) and IFNAR2 subunits, but differe...

Full description

Bibliographic Details
Main Authors: Yumeng Li, Asha Ashuo, Menghan Hao, Yaming Li, Jianyu Ye, Jiangxia Liu, Ting Hua, Zhong Fang, Jianhua Li, Zhenghong Yuan, Jieliang Chen
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Emerging Microbes and Infections
Subjects:
Interferon (IFN)
interferon alpha/beta receptor 1 (IFNAR1)
interferon alpha/beta receptor 2 (IFNAR2)
humanized mouse model
hepatitis B virus (HBV)
JAK/STAT signal pathway (JAK-STAT)
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2023.2287681

Internet

https://www.tandfonline.com/doi/10.1080/22221751.2023.2287681

Similar Items