Blockade of V‐domain immunoglobulin suppressor of T‐cell activation reprograms tumour‐associated macrophages and improves efficacy of PD‐1 inhibitor in gastric cancer

Blockade of V‐domain immunoglobulin suppressor of T‐cell activation reprograms tumour‐associated macrophages and improves efficacy of PD‐1 inhibitor in gastric cancer

Abstract Background and aims In gastric cancer, the response rate of programmed cell death protein‐1 (PD‐1) inhibitor is far from satisfactory, indicating additional nonredundant pathways might hamper antitumour immunity. V‐domain immunoglobulin suppressor of T‐cell activation (VISTA) has been repor...

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Bibliographic Details
Main Authors: Yifan Cao, Kuan Yu, Zihao Zhang, Yun Gu, Yichao Gu, Wandi Li, Weijuan Zhang, Zhenbin Shen, Jiejie Xu, Jing Qin
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:Clinical and Translational Medicine
Subjects:
gastric cancer
immunotherapy
PD‐1
tumour‐associated macrophages
VISTA
Online Access:https://doi.org/10.1002/ctm2.1578

Internet

https://doi.org/10.1002/ctm2.1578

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