Exploring mutation specific beta blocker pharmacology of the pathogenic late sodium channel current from patient-specific pluripotent stem cell myocytes derived from long QT syndrome mutation carriers

Exploring mutation specific beta blocker pharmacology of the pathogenic late sodium channel current from patient-specific pluripotent stem cell myocytes derived from long QT syndrome mutation carriers

The congenital long QT syndrome (LQTS), one of the most common cardiac channelopathies, is characterized by delayed ventricular repolarization underlying prolongation of the QT interval of the surface electrocardiogram. LQTS is caused by mutations in genes coding for cardiac ion channels or ion chan...

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Bibliographic Details
Main Authors: Thomas W. Comollo, Xinle Zou, Chuangeng Zhang, Divya Kesters, Thomas Hof, Kevin J. Sampson, Robert S. Kass
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Channels
Subjects:
Long QT syndrome
propranolol
induced pluripotent stems
Online Access:https://www.tandfonline.com/doi/10.1080/19336950.2022.2106025

Internet

https://www.tandfonline.com/doi/10.1080/19336950.2022.2106025

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