Optimization and validation of stability indicating RP-HPLC method for the quantification of gefitinib in bulk drug and nanoformulations: An application towards in vitro and ex vivo performance evaluation

Optimization and validation of stability indicating RP-HPLC method for the quantification of gefitinib in bulk drug and nanoformulations: An application towards in vitro and ex vivo performance evaluation

Gefitinib (GFB) is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor used primarily to treat non-small cell lung cancer (NSCLC), but it also works by lowering AKT and MAPK phosphorylation, which makes it effective against the breast cancer cells. A high-performance liquid chromato...

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Bibliographic Details
Main Authors: Pankaj Kumar, Bharti Mangla, Sarwar Beg, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Waleed H. Almalki, Shehla Nasar Mir Najib Ullah, Geeta Aggarwal
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Arabian Journal of Chemistry
Subjects:
Gefitinib
Breast cancer
Experimental design
Method validation
Marketed tablet
Permeationstudy
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535222006499

Internet

http://www.sciencedirect.com/science/article/pii/S1878535222006499

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