Afadin couples RAS GTPases to the polarity rheostat Scribble
Goudreault et al. investigate the role of Afadin downstream of RAS GTPases, substantiating this cell adhesion protein as a true RAS effector that couples its activation to cell polarity through the Scribble protein.
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32335-8 |
| _version_ | 1811315398359908352 |
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| author | Marilyn Goudreault Valérie Gagné Chang Hwa Jo Swati Singh Ryan C. Killoran Anne-Claude Gingras Matthew J. Smith |
| author_facet | Marilyn Goudreault Valérie Gagné Chang Hwa Jo Swati Singh Ryan C. Killoran Anne-Claude Gingras Matthew J. Smith |
| author_sort | Marilyn Goudreault |
| collection | DOAJ |
| description | Goudreault et al. investigate the role of Afadin downstream of RAS GTPases, substantiating this cell adhesion protein as a true RAS effector that couples its activation to cell polarity through the Scribble protein. |
| first_indexed | 2024-04-13T11:29:28Z |
| format | Article |
| id | doaj.art-584578dd8fc54fddaa7898fac918f30d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T11:29:28Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-584578dd8fc54fddaa7898fac918f30d2022-12-22T02:48:36ZengNature PortfolioNature Communications2041-17232022-08-0113111710.1038/s41467-022-32335-8Afadin couples RAS GTPases to the polarity rheostat ScribbleMarilyn Goudreault0Valérie Gagné1Chang Hwa Jo2Swati Singh3Ryan C. Killoran4Anne-Claude Gingras5Matthew J. Smith6Institute for Research in Immunology and Cancer, Université de MontréalInstitute for Research in Immunology and Cancer, Université de MontréalInstitute for Research in Immunology and Cancer, Université de MontréalInstitute for Research in Immunology and Cancer, Université de MontréalInstitute for Research in Immunology and Cancer, Université de MontréalLunenfeld-Tanenbaum Research Institute, Mount Sinai HospitalInstitute for Research in Immunology and Cancer, Université de MontréalGoudreault et al. investigate the role of Afadin downstream of RAS GTPases, substantiating this cell adhesion protein as a true RAS effector that couples its activation to cell polarity through the Scribble protein.https://doi.org/10.1038/s41467-022-32335-8 |
| spellingShingle | Marilyn Goudreault Valérie Gagné Chang Hwa Jo Swati Singh Ryan C. Killoran Anne-Claude Gingras Matthew J. Smith Afadin couples RAS GTPases to the polarity rheostat Scribble Nature Communications |
| title | Afadin couples RAS GTPases to the polarity rheostat Scribble |
| title_full | Afadin couples RAS GTPases to the polarity rheostat Scribble |
| title_fullStr | Afadin couples RAS GTPases to the polarity rheostat Scribble |
| title_full_unstemmed | Afadin couples RAS GTPases to the polarity rheostat Scribble |
| title_short | Afadin couples RAS GTPases to the polarity rheostat Scribble |
| title_sort | afadin couples ras gtpases to the polarity rheostat scribble |
| url | https://doi.org/10.1038/s41467-022-32335-8 |
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