The Fis Nucleoid Protein Negatively Regulates the Phase Variation fimS Switch of the Type 1 Pilus Operon in Enteropathogenic Escherichia coli

The Fis Nucleoid Protein Negatively Regulates the Phase Variation fimS Switch of the Type 1 Pilus Operon in Enteropathogenic Escherichia coli

In Escherichia coli the expression of type 1 pili (T1P) is determined by the site-specific inversion of the fimS ON–OFF switch located immediately upstream of major fimbrial subunit gene fimA. Here we investigated the role of virulence (Ler, GrlR, and GrlA) and global regulators (H-NS, IHF, and Fis)...

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Bibliographic Details
Main Authors: Zeus Saldaña-Ahuactzi, Jorge Soria-Bustos, Verónica I. Martínez-Santos, Jorge A. Yañez-Santos, Ygnacio Martínez-Laguna, María Lilia Cedillo-Ramirez, José L. Puente, Jorge A. Girón
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Microbiology
Subjects:
Fis
phase variation
fimS switch
type 1 pilus
EPEC
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.882563/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.882563/full

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