Nicotine regulates PCSK9 expression in HepG2 cells through Raf/MEK/ERK signaling pathway

Objective To investigate the effect of nicotine (NIC) on the expression of proprotein convertase subtilisin/kexin type 9 (PCSK9) and its molecular mechanism. Methods Different concentrations of NIC (0, 5, 10 and 20 μmol/L) were used to treat HepG2 cells for 0, 24 or 48 h to observe the change of PCS...

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Bibliographic Details
Main Authors: ZHOU Lin, XIANG Rui, MAO Min, FENG Rui, HU Yuhao
Format: Article
Language:zho
Published: Editorial Office of Journal of Army Medical University 2023-07-01
Series:陆军军医大学学报
Subjects:
Online Access:http://aammt.tmmu.edu.cn/html/202301028.htm