Genetic synergy between Acinetobacter baumannii undecaprenyl phosphate biosynthesis and the Mla system impacts cell envelope and antimicrobial resistance

Genetic synergy between Acinetobacter baumannii undecaprenyl phosphate biosynthesis and the Mla system impacts cell envelope and antimicrobial resistance

ABSTRACTAcinetobacter baumannii is a Gram-negative bacterial pathogen that poses a major health concern due to increasing multidrug resistance. The Gram-negative cell envelope is a key barrier to antimicrobial entry and includes an inner and outer membrane. The maintenance of lipid asymmetry (Mla) s...

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Bibliographic Details
Main Authors: Hannah R. Noel, Sowmya Keerthi, Xiaomei Ren, Jonathan D. Winkelman, Jerry M. Troutman, Lauren D. Palmer
Format: Article
Language:English
Published: American Society for Microbiology 2024-03-01
Series:mBio
Subjects:
Acinetobacter
antibiotic resistance
membrane stress
isoprenoid
Und-P
maintenance of lipid asymmetry
Online Access:https://journals.asm.org/doi/10.1128/mbio.02804-23

Internet

https://journals.asm.org/doi/10.1128/mbio.02804-23

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