The imbalance between Treg and Th17 cells caused by FTY720 treatment in skin allograft rejection

The imbalance between Treg and Th17 cells caused by FTY720 treatment in skin allograft rejection

OBJECTIVES: FTY720 modulates CD4+T cells by the augmentation of regulatory T cell activity, secretion of suppressive cytokines and suppression of IL-17 secretion by Th17 cells. To further understand the process of graft rejection/acceptance, we evaluated skin allograft survival and associated events...

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Bibliographic Details
Main Authors: Alessandra Gonçalves Commodaro, Juliana Figueredo Pedregosa, Jean Pierre Peron, Wesley Brandão, Luiz Vicente Rizzo, Valquiria Bueno
Format: Article
Language:English
Published: Elsevier España 2012-07-01
Series:Clinics
Subjects:
Transplantation
Rejection
Tolerance
FTY720
Foxp3
Th17
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012000700017

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012000700017

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