Assessing the clinical utility of genetic risk scores for targeted cancer screening

Assessing the clinical utility of genetic risk scores for targeted cancer screening

Abstract Background Genome-wide association studies have identified thousands of disease-associated single nucleotide polymorphisms (SNPs). A subset of these SNPs may be additively combined to generate genetic risk scores (GRSs) that confer risk for a specific disease. Although the clinical validity...

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Bibliographic Details
Main Authors: Carly A. Conran, Zhuqing Shi, William Kyle Resurreccion, Rong Na, Brian T. Helfand, Elena Genova, Siqun Lilly Zheng, Charles B. Brendler, Jianfeng Xu
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Translational Medicine
Subjects:
Genetic risk score
Single nucleotide polymorphism
Translational genomics
Cancer screening
Breast cancer
Prostate cancer
Online Access:https://doi.org/10.1186/s12967-020-02699-w

Internet

https://doi.org/10.1186/s12967-020-02699-w

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