iPSC‐derived NK cells with site‐specific integration of CAR19 and IL24 at the multi‐copy rDNA locus enhanced antitumor activity and proliferation

iPSC‐derived NK cells with site‐specific integration of CAR19 and IL24 at the multi‐copy rDNA locus enhanced antitumor activity and proliferation

Abstract The generation of chimeric antigen receptor‐modified natural killer (CAR‐NK) cells using induced pluripotent stem cells (iPSCs) has emerged as one of the paradigms for manufacturing off‐the‐shelf universal immunotherapy. However, there are still some challenges in enhancing the potency, saf...

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Bibliographic Details
Main Authors: Yuxuan Zhang, Qingxin Shi, Peiyun Wang, Chujun Huang, Shuqing Tang, Miaojin Zhou, Qian Hu, Lingqian Wu, Desheng Liang
Format: Article
Language:English
Published: Wiley 2024-05-01
Series:MedComm
Subjects:
chimeric antigen receptors
immunotherapy
induced pluripotent stem cells
interleukin 24
natural killer cells
Online Access:https://doi.org/10.1002/mco2.553

Internet

https://doi.org/10.1002/mco2.553

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