Influence of EGF and pro-NGF on EGFR/SORTILIN interaction and clinical impact in head and neck squamous cell carcinoma

Influence of EGF and pro-NGF on EGFR/SORTILIN interaction and clinical impact in head and neck squamous cell carcinoma

Head and Neck Squamous Cell Carcinoma (HNSCC) remains a cancer with a poor prognosis, with a 5-year survival rate of less than 50%. Although epidermal growth factor receptor (EGFR) is almost always overexpressed, targeted anti-EGFR therapies have modest efficacy and are mainly used in palliative car...

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Bibliographic Details
Main Authors: Martin Morisse, Thomas Bourhis, Romain Lévêque, Mathieu Guilbert, Julien Cicero, Martine Palma, Dominique Chevalier, Xuefen le Bourhis, Robert-Alain Toillon, Francois Mouawad
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Oncology
Subjects:
HNSCC
EGFR
Sortilin
pro-NGF
NGF
survival
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.661775/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.661775/full

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