L-cysteine methyl ester overcomes the deleterious effects of morphine on ventilatory parameters and arterial blood-gas chemistry in unanesthetized rats

L-cysteine methyl ester overcomes the deleterious effects of morphine on ventilatory parameters and arterial blood-gas chemistry in unanesthetized rats

We are developing a series of thiolesters that produce an immediate and sustained reversal of the deleterious effects of opioids, such as morphine and fentanyl, on ventilation without diminishing the antinociceptive effects of these opioids. We report here the effects of systemic injections of L-cys...

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Bibliographic Details
Main Authors: Paulina M. Getsy, Santhosh M. Baby, Walter J. May, James N. Bates, Christopher R. Ellis, Michael G. Feasel, Christopher G. Wilson, Tristan H. J. Lewis, Benjamin Gaston, Yee-Hsee Hsieh, Stephen J. Lewis
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
L-cysteine methylester
morphine
ventilatory depression
arterial blood-gas chemistry
Sprague Dawley rats
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.968378/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.968378/full

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