A bispecific, crosslinking lectibody activates cytotoxic T cells and induces cancer cell death

A bispecific, crosslinking lectibody activates cytotoxic T cells and induces cancer cell death

Abstract Background Aberrant glycosylation patterns play a crucial role in the development of cancer cells as they promote tumor growth and aggressiveness. Lectins recognize carbohydrate antigens attached to proteins and lipids on cell surfaces and represent potential tools for application in cancer...

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Bibliographic Details
Main Authors: Francesca Rosato, Rajeev Pasupuleti, Jana Tomisch, Ana Valeria Meléndez, Dajana Kolanovic, Olga N. Makshakova, Birgit Wiltschi, Winfried Römer
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Translational Medicine
Subjects:
Lectins
Tumor-associated carbohydrate antigens
Bispecific targeting
Globotriaosylceramide
Click chemistry
Cancer immunotherapy
Online Access:https://doi.org/10.1186/s12967-022-03794-w

Internet

https://doi.org/10.1186/s12967-022-03794-w

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