Investigation of Genetic Variants Associated with Tryptophan Metabolite Levels via Serotonin and Kynurenine Pathways in Patients with Bipolar Disorder

Investigation of Genetic Variants Associated with Tryptophan Metabolite Levels via Serotonin and Kynurenine Pathways in Patients with Bipolar Disorder

The kynurenine pathway (KP) may play a role in the pathophysiology of bipolar disorder (BD). We conducted a genome-wide association study (GWAS) to identify genetic variants associated with the plasma levels of the metabolites of tryptophan (TRP) via the serotonin (5-HT) and kynurenine (KYN) pathway...

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Bibliographic Details
Main Authors: Claudia Pisanu, Alessio Squassina, Pasquale Paribello, Stefano Dall’Acqua, Stefania Sut, Sofia Nasini, Antonella Bertazzo, Donatella Congiu, Anna Meloni, Mario Garzilli, Beatrice Guiso, Federico Suprani, Vittoria Pulcinelli, Maria Novella Iaselli, Ilaria Pinna, Giulia Somaini, Laura Arru, Carolina Corrias, Federica Pinna, Bernardo Carpiniello, Stefano Comai, Mirko Manchia
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Metabolites
Subjects:
bipolar disorder
GWAS
genome-wide association study
tryptophan
kynurenic acid
kynurenine
Online Access:https://www.mdpi.com/2218-1989/12/11/1127

Internet

https://www.mdpi.com/2218-1989/12/11/1127

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