Crabtree effect in kidney proximal tubule cells via late-stage glycolytic intermediates

Summary: The Crabtree effect is defined as a rapid glucose-induced repression of mitochondrial oxidative metabolism and has been described in yeasts and tumor cells. Using plate-based respirometry, we identified the Crabtree effect in normal (non-tumor) kidney proximal tubule epithelial cells (PTEC)...

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Bibliographic Details
Main Authors: Manjula Darshi, Jana Tumova, Afaf Saliba, Jiwan Kim, Judy Baek, Subramaniam Pennathur, Kumar Sharma
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223005394