Periadventitial Delivery of Simvastatin‐Loaded Microparticles Attenuate Venous Neointimal Hyperplasia Associated With Arteriovenous Fistula

Periadventitial Delivery of Simvastatin‐Loaded Microparticles Attenuate Venous Neointimal Hyperplasia Associated With Arteriovenous Fistula

Background Venous neointimal hyperplasia and venous stenosis (VS) formation can result in a decrease in arteriovenous fistula (AVF) patency in patients with end‐stage renal disease. There are limited therapies that prevent VNH/VS. Systemic delivery of simvastatin has been shown to reduce VNH/VS but...

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Bibliographic Details
Main Authors: Chenglei Zhao, Sean T. Zuckerman, Chuanqi Cai, Sreenivasulu Kilari, Avishek Singh, Michael Simeon, Horst A. von Recum, Julius N. Korley, Sanjay Misra
Format: Article
Language:English
Published: Wiley 2020-12-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
arteriovenous fistula
drug delivery
vascular remodeling
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.120.018418

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.120.018418

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