Intact Type I Interferon Receptor Signaling Prevents Hepatocellular Necrosis but Not Encephalitis in a Dose-Dependent Manner in Rift Valley Fever Virus Infected Mice

Intact Type I Interferon Receptor Signaling Prevents Hepatocellular Necrosis but Not Encephalitis in a Dose-Dependent Manner in Rift Valley Fever Virus Infected Mice

Rift Valley fever (RVF) is a zoonotic and emerging disease, caused by the RVF virus (RVFV). In ruminants, it leads to “abortion storms” and enhanced mortality rates in young animals, whereas in humans it can cause symptoms like severe hemorrhagic fever or encephalitis. The role of the innate and ada...

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Bibliographic Details
Main Authors: Lukas Mathias Michaely, Lukas Schuwerk, Lisa Allnoch, Kathleen Schön, Inken Waltl, Pia-Katharina Larsen, Andreas Pavlou, Chittappen Kandiyil Prajeeth, Guus F. Rimmelzwaan, Stefanie C. Becker, Ulrich Kalinke, Wolfgang Baumgärtner, Ingo Gerhauser
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
encephalitis
hepatic necrosis
mouse model
Rift Valley fever virus
type I interferon
Online Access:https://www.mdpi.com/1422-0067/23/20/12492

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https://www.mdpi.com/1422-0067/23/20/12492

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