17,20S(OH)<sub>2</sub>pD Can Prevent the Development of Skin Fibrosis in the Bleomycin-Induced Scleroderma Mouse Model

17,20S(OH)<sub>2</sub>pD Can Prevent the Development of Skin Fibrosis in the Bleomycin-Induced Scleroderma Mouse Model

Systemic sclerosis (SSc; scleroderma) is a chronic fibrotic disease involving TGF-β1. Low serum vitamin D (vit D) correlates with the degree of fibrosis and expression of TGF-β1. This study was designed to determine whether the noncalcemic vit D analog, 17,20S(OH)<sub>2</sub>pD, suppress...

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Bibliographic Details
Main Authors: Monica L. Brown Lobbins, Imara-Safi O. Scott, Andrzej T. Slominski, Karen A. Hasty, Sicheng Zhang, Duane D. Miller, Wei Li, Tae-Kang Kim, Zorica Janjetovic, Tejesh S. Patel, Linda K. Myers, Arnold E. Postlethwaite
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
vitamin D
scleroderma
TGF-β1
bleomycin model of fibrosis
collagen
cytokines
Online Access:https://www.mdpi.com/1422-0067/22/16/8926

Internet

https://www.mdpi.com/1422-0067/22/16/8926

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