Application of I-Optimal Design for Modeling and Optimizing the Operational Parameters of Ibuprofen Granules in Continuous Twin-Screw Wet Granulation

Application of I-Optimal Design for Modeling and Optimizing the Operational Parameters of Ibuprofen Granules in Continuous Twin-Screw Wet Granulation

The continuous twin-screw wet granulation (TSWG) process was investigated and optimized with prediction-oriented I-optimal designs. The I-optimal designs can not only obtain a precise estimation of the parameters that describe the effect of five input process parameters, including the screw speed, l...

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Bibliographic Details
Main Authors: Jie Zhao, Geng Tian, Haibin Qu
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Biomedicines
Subjects:
twin-screw wet granulation (TSWG)
I-optimal design
continuous manufacturing
process understanding
design space
Online Access:https://www.mdpi.com/2227-9059/11/7/2030

Internet

https://www.mdpi.com/2227-9059/11/7/2030

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