Downregulation of beclin 1 restores arsenite-induced impaired autophagic flux by improving the lysosomal function in cortex

Downregulation of beclin 1 restores arsenite-induced impaired autophagic flux by improving the lysosomal function in cortex

Arsenite is a toxic metalloid that causes various adverse effects in brain. However, the underlying mechanisms of arsenite-induced neurotoxicity remain poorly understood. In this study, both adult beclin 1+/+ and beclin 1+/- mice were employed to establish a model of chronic arsenite exposure by tre...

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Bibliographic Details
Main Authors: Hongmei Zhou, Hong Ling, Yunlong Li, Xuejun Jiang, Shuqun Cheng, Golamaully Mohammad Zubeir, Yinyin Xia, Xia Qin, Jun Zhang, Zhen Zou, Chengzhi Chen
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Arsenite
Beclin 1
Autophagy
Lysosomal dysfunction
Neurotoxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651321011787

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http://www.sciencedirect.com/science/article/pii/S0147651321011787

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