Development of Reduced Peptide Bond Pseudopeptide Michael Acceptors for the Treatment of Human African Trypanosomiasis

Development of Reduced Peptide Bond Pseudopeptide Michael Acceptors for the Treatment of Human African Trypanosomiasis

Human African Trypanosomiasis (HAT) is an endemic protozoan disease widespread in the sub-Saharan region that is caused by <i>T. b. gambiense</i> and <i>T. b. rhodesiense</i>. The development of molecules targeting rhodesain, the main cysteine protease of <i>T. b. rhode...

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Bibliographic Details
Main Authors: Santo Previti, Roberta Ettari, Carla Di Chio, Rahul Ravichandran, Marta Bogacz, Ute A. Hellmich, Tanja Schirmeister, Sandro Cosconati, Maria Zappalà
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
sleeping sickness
Michael acceptors
peptide backbone modifications
antitrypanosomal agents
rhodesain
pseudopeptides
Online Access:https://www.mdpi.com/1420-3049/27/12/3765

Internet

https://www.mdpi.com/1420-3049/27/12/3765

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