Measurement of selection coefficients from genomic samples of adapting populations by computer modeling

Summary: The existing protocols of measuring the selection coefficients of loci neglect linkage effects existing between loci. This protocol is free from this limitation. The protocol inputs a set of DNA sequences at three time points, removes conserved sites, and estimates selection coefficients. I...

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Bibliographic Details
Main Authors: Igor V. Likhachev, Igor M. Rouzine
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:STAR Protocols
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166722007018