PROTAC-induced protein structural dynamics in targeted protein degradation

PROTAC-induced protein structural dynamics in targeted protein degradation

PROteolysis TArgeting Chimeras (PROTACs) are small molecules that induce target protein degradation via the ubiquitin-proteasome system. PROTACs recruit the target protein and E3 ligase; a critical first step is forming a ternary complex. However, while the formation of a ternary complex is crucial,...

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Detaylı Bibliyografya
Asıl Yazarlar: Kingsley Y Wu, Ta I Hung, Chia-en A Chang
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: eLife Sciences Publications Ltd 2025-02-01
Seri Bilgileri:eLife
Konular:
drug development
targeted protein degradation
structural dynamic
conformational sampling
molecular modeling
molecular mechanics
Online Erişim:https://elifesciences.org/articles/101127

Internet

https://elifesciences.org/articles/101127

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