A novel epitope from CD22 regulates Th1 and Th17 cell function in systemic lupus erythematosus.

A novel epitope from CD22 regulates Th1 and Th17 cell function in systemic lupus erythematosus.

The published antibodies (Abs) against CD22 on B cells including Epratuzumab could inhibit B cell activation mainly through binding to C2-set Ig domain of CD22, but they are rarely reported to modulate the pathogenic CD4(+) T cell function in systemic lupus erythematosus (SLE). Recently, it was prov...

Full description

Bibliographic Details
Main Authors: Jing Yuan, Miao Yu, Ai-Lin Cao, Xiao Chen, Li-Hua Zhang, You Song, Xiang Cheng, Zi-Hua Zhou, Min Wang, He-Ping Guo, Rong Du, Yu-Hua Liao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3660346?pdf=render

Internet

http://europepmc.org/articles/PMC3660346?pdf=render

Similar Items