Pten dose dictates cancer progression in the prostate.

Pten dose dictates cancer progression in the prostate.

Complete inactivation of the PTEN tumor suppressor gene is extremely common in advanced cancer, including prostate cancer (CaP). However, one PTEN allele is already lost in the vast majority of CaPs at presentation. To determine the consequence of PTEN dose variations on cancer progression, we have...

Full description

Bibliographic Details
Main Authors: Lloyd C Trotman, Masaru Niki, Zohar A Dotan, Jason A Koutcher, Antonio Di Cristofano, Andrew Xiao, Alan S Khoo, Pradip Roy-Burman, Norman M Greenberg, Terry Van Dyke, Carlos Cordon-Cardo, Pier Paolo Pandolfi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2003-12-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC270016?pdf=render

Internet

http://europepmc.org/articles/PMC270016?pdf=render

Similar Items