Intrapleural Injection of Anti-PD1 Antibody: A Novel Management of Malignant Pleural Effusion

Intrapleural Injection of Anti-PD1 Antibody: A Novel Management of Malignant Pleural Effusion

BackgroundMalignant tumors accompanied with malignant pleural effusion (MPE) often indicate poor prognosis. The therapeutic effect and mechanism of intrapleural injection of anti-programmed cell death protein 1 (PD1) on MPE need to be explored.MethodsA preclinical MPE mouse model and a small clinica...

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Bibliographic Details
Main Authors: Xinying Li, Guannan Wu, Cen Chen, Yuan Zhao, Suhua Zhu, Xincui Song, Jie Yin, Tangfeng Lv, Yong Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Immunology
Subjects:
malignant pleural effusion (MPE)
intrapleural injection
anti-PD1
cytotoxic T lymphocyte (CTL)
tumor microenvironment (TME)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.760683/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.760683/full

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