LYN kinase programs stromal fibroblasts to facilitate leukemic survival via regulation of c-JUN and THBS1

LYN kinase programs stromal fibroblasts to facilitate leukemic survival via regulation of c-JUN and THBS1

The survival of chronic lymphocytic leukemia cells strongly depends on the presence of a supportive microenvironment. Here, the authors show that LYN kinase is essential for the reprogramming of stromal cells towards a leukemia-supportive phenotype that facilitates disease progression.

Bibliographic Details
Main Authors: Alexander F. vom Stein, Rocio Rebollido-Rios, Anna Lukas, Maximilian Koch, Anton von Lom, Sebastian Reinartz, Daniel Bachurski, France Rose, Katarzyna Bozek, Ali T. Abdallah, Viktoria Kohlhas, Julia Saggau, Rebekka Zölzer, Yue Zhao, Christiane Bruns, Paul J. Bröckelmann, Philipp Lohneis, Reinhard Büttner, Björn Häupl, Thomas Oellerich, Phuong-Hien Nguyen, Michael Hallek
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36824-2

Internet

https://doi.org/10.1038/s41467-023-36824-2

Similar Items