Effects of exposure in utero to buprenorphine on oxidative stress and apoptosis in the hippocampus of rat pups

Effects of exposure in utero to buprenorphine on oxidative stress and apoptosis in the hippocampus of rat pups

The study investigated the effect of buprenorphine (BUP) on oxidative indices and gene expression of apoptotic molecules in the hippocampus of neonates during the fetal stage. BUP (1 or 0.5 mg/kg) was subcutaneously administrated to pregnant rat dams. After parturition, the pups were maintained to t...

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Bibliographic Details
Main Authors: Saeed Samarghandian, Fahimeh Ghasemi, Hamed Aramjoo, Fariborz Samini, Michael Aschner, Babak Roshanravan, Tahereh Farkhondeh
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Toxicology Reports
Subjects:
Buprenorphine
Apoptosis
Oxidative stress
Brain
Rat
Pup
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750022000300

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http://www.sciencedirect.com/science/article/pii/S2214750022000300

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