Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels

Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels

Some p53 mutants promote invasive migration of cancer cells and metastasis of tumours in vivo. However the key mechanistic details behind these phenomena remain unclear. Here the authors propose a non-cell autonomous mechanism involving fibroblasts, whereby mutant p53-expressing cancer cells activat...

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Bibliographic Details
Main Authors: David Novo, Nikki Heath, Louise Mitchell, Giuseppina Caligiuri, Amanda MacFarlane, Dide Reijmer, Laura Charlton, John Knight, Monika Calka, Ewan McGhee, Emmanuel Dornier, David Sumpton, Susan Mason, Arnaud Echard, Kerstin Klinkert, Judith Secklehner, Flore Kruiswijk, Karen Vousden, Iain R. Macpherson, Karen Blyth, Peter Bailey, Huabing Yin, Leo M. Carlin, Jennifer Morton, Sara Zanivan, Jim C. Norman
Format: Article
Language:English
Published: Nature Portfolio 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07339-y

Internet

https://doi.org/10.1038/s41467-018-07339-y

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