Creation and preclinical evaluation of genetically attenuated malaria parasites arresting growth late in the liver

Creation and preclinical evaluation of genetically attenuated malaria parasites arresting growth late in the liver

Abstract Whole-sporozoite (WSp) malaria vaccines induce protective immune responses in animal malaria models and in humans. A recent clinical trial with a WSp vaccine comprising genetically attenuated parasites (GAP) which arrest growth early in the liver (PfSPZ-GA1), showed that GAPs can be safely...

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Main Authors: Blandine Franke-Fayard, Catherin Marin-Mogollon, Fiona J. A. Geurten, Séverine Chevalley-Maurel, Jai Ramesar, Hans Kroeze, Els Baalbergen, Els Wessels, Ludivine Baron, Valérie Soulard, Thomas Martinson, Maya Aleshnick, Antonius T. G. Huijs, Amit K. Subudhi, Yukiko Miyazaki, Ahmad Syibli Othman, Surendra Kumar Kolli, Olivia A. C. Lamers, Magali Roques, Rebecca R. Stanway, Sean C. Murphy, Lander Foquet, Diana Moita, António M. Mendes, Miguel Prudêncio, Koen J. Dechering, Volker T. Heussler, Arnab Pain, Brandon K. Wilder, Meta Roestenberg, Chris J. Janse
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-022-00558-x

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https://doi.org/10.1038/s41541-022-00558-x

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