Differential lipid signaling from CD4+ and CD8+ T cells contributes to type 1 diabetes development

Differential lipid signaling from CD4+ and CD8+ T cells contributes to type 1 diabetes development

IntroductionWe reported that Ca2+-independent phospholipase A2β (iPLA2β)–derived lipids (iDLs) contribute to type 1 diabetes (T1D) onset. As CD4+ and CD8+ T cells are critical in promoting β-cell death, we tested the hypothesis that iDL signaling from these cells participates in T1D development. Met...

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Bibliographic Details
Main Authors: Tayleur D. White, Abdulaziz Almutairi, Ying Gai-Tusing, Daniel J. Stephenson, Benjamin D. Stephenson, Charles E. Chalfant, Xiaoyong Lei, Brian Lu, Bruce D. Hammock, Teresa P. DiLorenzo, Sasanka Ramanadham
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-09-01
Series:Frontiers in Immunology
Subjects:
T-lymphocytes
lipid signaling
type 1 diabetes
adoptive transfer
islet microscopy
flow cytometry
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1444639/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1444639/full

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