Lipid metabolism dysfunction induced by age-dependent DNA methylation accelerates aging

Lipid metabolism dysfunction induced by age-dependent DNA methylation accelerates aging

Abstract Epigenetic alterations and metabolic dysfunction are two hallmarks of aging. However, the mechanism of how their interaction regulates aging, particularly in mammals, remains largely unknown. Here we show ELOVL fatty acid elongase 2 (Elovl2), a gene whose epigenetic alterations are most hig...

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Bibliographic Details
Main Authors: Xin Li, Jiaqiang Wang, LeYun Wang, Yuanxu Gao, Guihai Feng, Gen Li, Jun Zou, Meixin Yu, Yu Fei Li, Chao Liu, Xue Wei Yuan, Ling Zhao, Hong Ouyang, Jian-Kang Zhu, Wei Li, Qi Zhou, Kang Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2022-05-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-022-00964-6

Internet

https://doi.org/10.1038/s41392-022-00964-6

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