APOE ε4/ε4 homozygotes with early Alzheimer's disease show accelerated hippocampal atrophy and cortical thinning that correlates with cognitive decline

APOE ε4/ε4 homozygotes with early Alzheimer's disease show accelerated hippocampal atrophy and cortical thinning that correlates with cognitive decline

Abstract Introduction Hippocampal volume (HV) and cortical thickness are commonly used imaging biomarkers in Alzheimer's disease (AD) trials, and may have utility as selection criteria for enrichment strategies. Atrophy rates of these measures, in the high‐risk apolipoprotein E (APOE) ε4/ε4 hom...

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Bibliographic Details
Main Authors: Susan Abushakra, Anton P. Porsteinsson, Marwan Sabbagh, Luc Bracoud, Joel Schaerer, Aidan Power, John A. Hey, David Scott, Joyce Suhy, Martin Tolar, for the Alzheimer's Disease Neuroimaging Initiative
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Subjects:
ALZ‐801
Alzheimer's disease
amyloid beta
amyloid oligomers
apolipoprotein E ε4/ε4 homozygotes
biomarkers
Online Access:https://doi.org/10.1002/trc2.12117

Internet

https://doi.org/10.1002/trc2.12117

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