Antitumor Effect of Simvastatin in Combination With DNA Methyltransferase Inhibitor on Gastric Cancer via GSDME-Mediated Pyroptosis

Antitumor Effect of Simvastatin in Combination With DNA Methyltransferase Inhibitor on Gastric Cancer via GSDME-Mediated Pyroptosis

Gasdermin E (GSDME) is one of the executors of pyroptosis, a type of programmed lytic cell death, which can be triggered by caspase-3 activation upon stimulation. Silenced GSDME expression due to promoter hypermethylation is associated with gastric cancer (GC), which is confirmed in the present stud...

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Bibliographic Details
Main Authors: Ying Xia, Yong Jin, Daxiang Cui, Xia Wu, Cunfeng Song, Weilin Jin, Hai Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Subjects:
GSDME
pyroptosis
DNA methyltransferase inhibitor
gastric cancer
simvastatin
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.860546/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.860546/full

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