Heregulin Activity Assays for Residual Testing of Cell Therapy Products

Heregulin Activity Assays for Residual Testing of Cell Therapy Products

Abstract Background Heregulin is a ligand for the protooncogene product ErbB/HER that acts as  a key mitogenic factor for human Schwann cells (hSCs). Heregulin is required for sustained hSC growth in vitro but must be thoroughly removed before cell collection for transplantation due to potential saf...

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Bibliographic Details
Main Authors: Paula V. Monje, Ketty Bacallao, Gabriela I. Aparicio, Anil Lalwani
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Biological Procedures Online
Subjects:
Schwann cells
Peripheral nerve
In vitro culture
Autologous cell therapy
Residual testing
Quality control
Online Access:https://doi.org/10.1186/s12575-021-00157-5

Internet

https://doi.org/10.1186/s12575-021-00157-5

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