Genome-scale annotation of protein binding sites via language model and geometric deep learning

Revealing protein binding sites with other molecules, such as nucleic acids, peptides, or small ligands, sheds light on disease mechanism elucidation and novel drug design. With the explosive growth of proteins in sequence databases, how to accurately and efficiently identify these binding sites fro...

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Bibliographic Details
Main Authors: Qianmu Yuan, Chong Tian, Yuedong Yang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-04-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/93695